Large study illustrates cardiac CT can effectively assess coronary artery disease

Cardiac CT can effectively assess coronary artery stenosis, according to a large study performed at Leiden University Medical Center in Leiden, The Netherlands.

The study consisted of 1,331 patients who had suspected coronary artery disease with 50% or more stenosis. 10,561 coronary artery segments were analyzed during the study. "We found a 98% sensitivity rate for detecting significant coronary artery stenosis in our patients; specificity was 91%," said Lucia J.M. Kroft, MD, and Alexander Meijer, MSc, lead authors of the study.

"The results indicate that in patients with an intermediate clinical probability of coronary artery disease, cardiac CT scans may avoid the use of invasive catheter angiography. Catheter-based angiography is currently the gold standard for coronary artery evaluation, but it is an invasive technique, has a small percentage of "major" complications and it is relatively expensive," said Drs. Kroft and Meijer.

"Radiologists, cardiologists, their patients, medical policy makers and financial controllers all have a stake in learning about the accuracy and usefulness of computer generated images of the heart. Every year, millions of people worldwide come to the emergency room with acute chest pain," said Dr. Kroft. "Multi-slice CT is increasingly being used as a daily practice in the evaluation of these patients and yet, up until now, its efficacy has not been proven. Our study has made a contribution to that direction," said Dr. Meijer.

This study appears in the December issue of the American Journal of Roentgenology. For a copy of the full study, please contact Heather Curry via email at hcurry@arrs.org.

The American Roentgen Ray Society (ARRS) was founded in 1900 and is the oldest radiology society in the United States. Its monthly journal, the American Journal of Roentgenology, began publication in 1906. Radiologists from all over the world attend the ARRS annual meeting to participate in instructional courses, scientific paper presentations and scientific and commercial exhibits related to the field of radiology. The Society is named after the first Nobel Laureate in Physics, Wilhelm Röentgen, who discovered the x-ray in 1895.