The exact pathophysiology of IBS remains unknown. Clinically, the symptoms of IBS are associated with psychological stress, food intolerance, intestinal infections, and even previous abdominal surgeries. Recent interest has also been directed to the possible participation of the mucosa in the pathophysiology of IBS. Inflammatory mediators could be leading to intestinal dysfunction and a consequent increase of intestinal permeability.
This clinical research article to be published on May 21, 2008 in the World Journal of Gastroenterology addresses this question. Dr Soares RLS et al compared the results of skin prick test (SPT) for inhalant (IA) and food (FA) allergens in two sub-types of IBS patients.
In this study, the presence of diarrhea in IBS was a significant factor for the higher cutaneous reactivity response to food antigens. The results of study is in agreement with other studies. Dr Soares RLS et al suggest that in IBS sub-type diarrhea the epithelial function (intestinal permeability) can be especially altered.
In the view of the authors, this study adds new information for a better understanding of the relationship between increased permeability intestinal and intestinal inflammation in IBS patients. IBS is defined symptom criteria rather than biological markers. No diagnostic tests are available. The treatment is also selected based on the predominant symptom. Due to the high incidence of IBS around the world and no effective treatment at present, this case reported by Dr Soares RLS is surely worth the attention of both doctors and the public at large.
Results of this study gave a clear delineation of the research background and provided important data about pathophysiological changes in IBS.
Journal
World Journal of Gastroenterology