Interferon-gamma receptor 1 (IFN-γR1) mediates the rejection of haematopoietic stem cells
In research published in PLoS Medicine, Clare Soudais (Institut National de la Santé et de la Recherche Médicale, Paris) and colleagues investigated the mechanism of rejection of hematopoietic stem cell transplants in patients with a rare life threatening disorder of the immune system known as interferon-gamma receptor 1 (IFN-γR1) deficiency. They show that IFN-γ is an anti-hematopoietic cytokine in vivo.
Citation: Rottman M, Soudais C, Vogt G, Renia L, Emile JF, et al. (2008) IFN-c mediates the rejection of haematopoietic stem cells in IFNcR1- deficient hosts. PLoS Med 5(1): e26.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050026
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-01-soudais.pdf
CONTACT: Claire Soudais
INSERM U550
Laboratory of Human Genetics of Infectious Diseases,
Paris, 75015
France
+33 662 177 614
+33 140 615 688 (fax)
soudais@necker.fr
FROM THE PLoS MEDICINE MAGAZINE SECTION:
Medical graduates from low income countries must remain free to emigrate
The current debate about the brain drain of health professionals from low-income countries such as Pakistan to the rich world often demonizes medical graduates who choose to leave their countries, say Zarmeneh Aly (medical student) and Fawad Taj (research associate) from Aga Khan University, Pakistan. "But what is forgotten in this debate," they say "is that some doctors who emigrate to the West have every intention of returning after their higher-level training overseas."
The authors examine the reasons why Pakistani medical graduates often emigrate to the West, and argue that some of these graduates have every intention of returning to Pakistan after higher training abroad. By undertaking specialty training abroad, they say, "we'll come back better equipped with the technical know-how and academic expertise synonymous with postgraduate training in the West, with new ideas and challenges, and with the immense task of adapting our expertise to the local environment of our homeland."
Citation: Aly Z, Taj F (2008) Why Pakistani medical graduates must remain free to emigrate. PLoS Med 5(1): e2.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050002
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-01-aly.pdf
CONTACT: Zarmeneh Aly
Aga Khan University
Medical college
Stadium Road
Karachi, Sindh 74800
Pakistan
+92 321-7514060
zarmenehaly@gmail.com
About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org
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