Cells communicate with their environment through molecules on their surface known as receptors. Receptors bind ligands - specific companion molecules that either carry information about the outside environment or are critical cell nutrients. A variety of receptors are internalized into the cell through a process known as endocytosis. Receptors display a wide range of state-dependent endocytosis rates, but the functional significance of these patterns is not well understood.
In a paper publishing today (June 1) in the Open Access journal PLoS Computational Biology, Drs. Shankaran, Resat and Wiley from the Pacific Northwest National Laboratory employ a generalized mathematical model to comparatively explore the design principles of signal transduction and transport receptors.
The authors use a new module-based systems theory approach along with quantitative metrics for network function and robustness to show that endocytosis and other receptor/ligand properties can be described by just a few control parameters. Using mathematical analysis, the authors show that the efficiency and robustness of receptor systems are encoded by two fundamental parameters: the avidity which quantifies the ability of a receptor system to capture ligand, and the consumption which quantifies the ability to internalize bound ligand.
By examining a number of receptor systems, the authors demonstrate that the response of receptor systems can be characterized as being: i) avidity-controlled, which depends primarily on ligand capture efficiency, ii) consumption-controlled where the ability to internalize surface-bound ligand is the primary control parameter, and iii) dual-sensitive, in which both the avidity and consumption parameters are important. The location of various receptor systems in control parameter space dictates their specific function and regulation.
Most significantly, the authors argue that the evolution of a given receptor system can be understood in terms of its optimal location in avidity-consumption parameter space. For example, induced endocytosis can be shown to be an optimal solution for achieving high fidelity information transmission for signaling receptors. Overall, this study develops and applies a new strategy for quantifying the phenotype of complex systems that should be generally applicable to a wide range of problems in systems biology research.
The research was funded by the National Institutes of Health and the Biomolecular Systems Initiative at PNNL.
CITATION: Shankaran H, Resat H, Wiley HS (2007) Cell Surface Receptors for Signal Transduction and Ligand Transport: A Design Principles Study. PLoS Comput Biol 3(6): e101 doi:10.1371/journal.pcbi.0030101
CONTACT:
Haluk Resat
Pacific Northwest National Laboratory
Computational Biology and Bioinformatics
P.O. Box 999, MS: K7-90
Richland, WA 99352
United States of America
509-372-6340
509-372-4720 (fax)
haluk.resat@pnl.gov
PLEASE MENTION THE OPEN-ACCESS JOURNAL PLoS COMPUTATIONAL BIOLOGY (www.ploscompbiol.org) AS THE SOURCE FOR THIS ARTICLE AND PROVIDE A LINK TO THE FREELY-AVAILABLE TEXT. THANK YOU.
PLoS Computational Biology is an open access, peer reviewed journal published weekly by the Public Library of Science (PLoS) in association with the International Society for Computational Biology (ISCB).
Journal
PLoS Computational Biology