News Release

Pregnancy news -- Preterm delivery risk reduced by high-dose progesterone treatment

March of Dimes award recognizes new research

Grant and Award Announcement

March of Dimes Foundation

SAN FRANCISCO, CA (Feb. 8, 2007) -- Researchers at the 27th Annual Society for Maternal-Fetal Medicine (SMFM) meeting announced today that high-dose progesterone treatment helped at-risk pregnant women avoid premature delivery. A preterm birth can have serious consequences to the baby, including cerebral palsy, mental retardation, chronic lung disease, blindness and hearing loss.

In this study, 45 hospitalized women who already had experienced premature labor (before 37 weeks of pregnancy) were randomly divided into a treatment group and an observation group. The 23 members of the treatment group received twice-weekly 341-mg doses of progesterone until week 36. The progesterone injections appeared to prevent continued shortening of the cervix, a factor in premature labor.

"Our purpose was to determine if a higher dose of alpha hydroxy-progesterone caproate (17P), commonly used now to prevent preterm birth among women with that history, can affect cervical changes and thus increase preventive effectiveness in women during their first pregnancy." said Fabio Facchinetti, M.D., of the Universita di Modena e Reggio Emilia (Modena, Italy,) the lead study author and SMFM member. "And, our finding was that 22 percent of the women in the high-dose treatment group had a preterm delivery, compared to 54 percent of those in the observation group. We believe this was the result of reduced cervical shortening and inhibited local inflammation." Dr. Facchinetti said that in an unrelated study, similar 17P treatment reduced the risk of preterm delivery by 85 percent.

"Dr. Facchinetti's research is critical to identifying another effective tool for helping pregnancies go as close to full-term as possible," said Diane Ashton, M.D., MPH, deputy medical director of the March of Dimes. "It appears that this comparatively simple treatment can help prevent premature birth, which can have truly devastating effects on a baby."

The study, Alpha Hydroxy-Progesterone Caproate (17P) Treatment Reduces Cervical Shortening InhibitingCervical Interleukin-1 Secretion, is the first to address the relationship between progesterone, cervical changes, and preterm deliveries. It is the fourth study by SMFM members to be honored by the March of Dimes for honing the tools used in the fight against prematurity. The March of Dimes is conducting a multi-year, multi-million-dollar campaign aimed at using research and awareness to reduce the growing rate of premature births.

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For interviews with study authors contact Sanda Pecina (703-967-2676) or Matt Taylor (202-367-1631).

The Society for Maternal-Fetal Medicine (est. 1977) is a non-profit membership group for obstetricians/gynecologists who have additional formal education and training in maternal-fetal medicine. The society is devoted to reducing high-risk pregnancy complications by continuously educating its 2000 members on the latest pregnancy assessment and treatment methods. It also serves as an advocate for improving public policy, and expanding research funding and opportunities for maternal-fetal medicine. The group hosts an annual scientific meeting in which new ideas and research in the area of maternal-fetal medicine are unveiled and discussed. For more information, visit www.smfm.org.

The March of Dimes is a national voluntary health agency whose mission is to improve the health of babies by preventing birth defects, premature birth and infant mortality. Founded in 1938, the March of Dimes funds programs of research, community services, education, and advocacy. For more information, visit the March of Dimes Web site at www.marchofdimes.com or its Spanish language Web site at www.nacersano.org.


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