New synthetic methodology for biologically relevant nitrogen heterocycles. - Prof. F.P.J.T. (Floris) Rutjes (Radboud University)
Nitrogen heterocycles are found in a large number of biologically active compounds and medicines. It is important to develop versatile methods to synthesize these ring systems. This project is developing a new synthesis methodology.
Single metal nanoparticle in catalytic action - Prof. B.M. (Bert) Weckhuysen (Utrecht University)
In this research project the researcher wants to use an optical sonde to scan a catalyst surface, illuminate this and at the same time allow catalytic reactions to take place. A special reactor will be developed for this purpose and one active nanoparticle will be zoomed in on. This must lead to more efficient catalysts and the development of more environmentally-friendly chemical processes.
The ECHO project grant (for Excellent Chemical Research) generates space for creative, science-driven research which can form the basis for future scientific themes. In November 2005, 79 researchers submitted a proposal and 29 of these were approved. Two of the proposals are briefly described below; the complete list can be found via www.nwo.nl/cw/echo.
The puzzling behaviour of ultrasmall magnets - Prof. A.P. (Albert) Philipse (Utrecht University)
Alcohol and water are in part fluid because the molecules act as small magnets. Are tiny magnets alone sufficient for fluid formation? Theoreticians have disputed this for years. The applicant wants to find out who is right by simulating invisible molecules with tiny magnetic iron oxide spheres.
Quality control for enzymes taken up in peroxisomes? Prof. I.J. (Ida) van der Klei (University of Groningen)
Peroxisomes are important cell organelles which play a role in various metabolic processes. This study intends to investigate whether peroxisomal enzymes, which are synthesised in the cell fluid, are checked for their functionality (correct folding and assembly) and the roles folding and assembly play in the uptake of the protein by the target organelle, the peroxisome.