Unlike some other microcapsules, which release their drug cargo only when exposed to ultrasonic waves or another external trigger, the new system relies on internal mechanisms to do the same job. Each of the new microparticles features a biodegradable gel core that is surrounded by a lipid membrane. As the gel biodegrades, pressure builds up in the membrane. Eventually the microcapsule ruptures, releasing the medication.
The system, the researchers note, could change how some vaccines are administered. Instead of an initial injection followed by a series of boosters, for instance, certain vaccines could be given in a single shot with the "booster" microcapsules timed to rupture at appropriate intervals.
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The online version of the research paper cited above was initially published Nov. 24 on the journal's Web site. Journalists can arrange access to this site by sending an e-mail to newsroom@acs.org or calling the contact person for this release.
Journal
Biomacromolecules