"As the community of scientists on the front lines of the battle against cancer, we are firm in our belief that continued experimentation with human stem cells is necessary to improve evaluation of anti-cancer drugs, to identify markers for early detection of cancer, and to illuminate the path to novel, targeted treatments," said Lynn M. Matrisian, Ph.D., AACR past president and Ingram Distinguished Professor of Cancer Research at Vanderbilt University in Nashville, Tenn.
"Our belief is based on the results of peer-reviewed research, the strength of professional integrity and long-standing ethical principles, and profound respect for human life," added Matrisian, who also is professor and chair of the department of cancer biology at Vanderbilt.
The association's statement is equally vehement in its rejection of any technology, including stem cell technology, used in human reproductive cloning, noting that, "such attempts have no beneficial goal and can be reasonably assumed to cause harm." At the same time, the AACR position supports the "ethical use of somatic cell nuclear transfer," noting that the technique, "promises to reveal the role of specific genetic alterations in tumorigenesis and further refine evaluations of drug activity, as well as generate immune-compatible material for transplant therapies."
The primary points of the AACR position on stem cell biology are:
In light of the recent cloning of patient-specific human embryonic stem cells by researchers in South Korea, AACR Science Policy and Legislative Affairs Committee Chairman William G. Nelson V, M.D., Ph.D., pointed to the clause in the AACR position statement encouraging grant-making institutions to "work toward stable and sufficient funding for meritorious stem cell projects, free of political uncertainty, so that young investigators are encouraged to devote their careers to this important field."
Said Nelson, professor in the departments of Oncology, Urology, Pharmacology and Molecular Sciences, Medicine, Pathology, and Radiation Oncology and Molecular Radiation Sciences, at Johns Hopkins University, "The United States is so closely associated with scientific advancements that the first question on everyone's mind was, 'why wasn't this huge medical breakthrough made by Americans?'
"Sadly," he continued, "American stem cell biology suffers from a small and unsteady flow of graduate students, post-doctoral fellows and early-career faculty. No scientific discipline can grow without the constant infusion of new talent and new ideas."
Founded in 1907, the American Association for Cancer Research is a professional society of more than 24,000 laboratory, translational, and clinical scientists engaged in all areas of cancer research in the United States and in more than 60 other countries. AACR's mission is to accelerate the prevention and cure of cancer through research, education, communication, and advocacy. Its principal activities include the publication of five major peer-reviewed scientific journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. AACR's Annual Meetings attract more than 16,000 participants who share new and significant discoveries in the cancer field. Specialty meetings, held throughout the year, focus on the latest developments in all areas of cancer research.