"Our findings may be important in screening practices for children with either of these conditions," said the study's leader, pediatric endocrinologist Lorraine E. Levitt Katz, M.D., of The Children's Hospital of Philadelphia. "Obese children with neuropsychiatric conditions should be screened for diabetes, and children with insulin resistance or type 2 diabetes should be screened for psychiatric conditions."
The researchers found that 46 (19 percent) of 237 children at Children's Hospital diagnosed with type 2 diabetes had previously been diagnosed with neuropsychiatric disease (NPD). The retrospective study, the first to report the frequency of NPD in a cohort of children with type 2 diabetes, appears in the June issue of Pediatric Diabetes.
"Of the subset of children in our sample with neuropsychiatric disorders, a substantial number were treated with psychiatric medications reported to cause weight gain," said Robert Berkowitz, M.D., chief of Psychiatry at Children's Hospital, and senior author of the study. "However, this is not the only factor at work, as not all of the medications cause weight gain. Depression, as well as other neuropsychiatric illnesses, may itself lead to a sedentary lifestyle, which places children at risk for type 2 diabetes."
While this study examined previously diagnosed neuropsychiatric disease, the true frequency of neuropsychiatric conditions in children with type 2 diabetes may be considerably higher, say the researchers. "For some children, diabetes may occur first, and help contribute to depression and other NPDs," Dr. Berkowitz added. "Some researchers suspect that both depression and diabetes have a common basis in the neuroendocrine system, and one disease may help to stimulate the other."
Type 2 diabetes, formerly called adult-onset diabetes and still most common in adults, has been increasing sharply among children over the past decade, in parallel with growing numbers of overweight and obese children. Type 2 diabetes has especially been rising among African American adolescents, who comprised a majority of the patients in the current study.
Although the most effective treatment for type 2 diabetes in children is not known, The Children's Hospital of Philadelphia is participating in a national multicenter trial, comparing medication with the effects of lifestyle changes such as diet and increased exercise.
"For most children, a diagnosis of diabetes demands dramatic lifestyle changes," added Dr. Katz. "If the child has a neuropsychiatric disease as well, there are additional challenges, which physicians and caregivers need to factor into the child's treatment to achieve the best results."
In addition to Drs. Katz and Berkowitz, co-authors were Sanjeev Swami, M.D., Maire Abraham, Kathryn M. Murphy, Abbas F. Jawad, Ph.D., and Heather McKnight-Menci, all of The Children's Hospital of Philadelphia.
About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking second in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 430-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit www.chop.edu.
Journal
Pediatric Diabetes