The three organizations initially intended to develop a practice guideline about treatment for polyneuropathy, a noninflammatory nerve disease. The definition of polyneuropathy was inconsistent in available studies, making it impossible to compare the studies and make recommendations for practice. This led to the decision to write a case definition.
"Where case definitions have been developed, they have improved clinical research," said co-author John D. England, MD, of Deaconess Billings Clinic in Billings, Mont.
The author panel evaluated the diagnostic accuracy of the predictors of polyneuropathy and used an extensive literature review and a formal consensus process to develop an approach ranked by the likelihood of disease.
According to the definition, the combination of neuropathic symptoms, signs, and abnormal electrodiagnostic studies provides the most accurate diagnosis of distal symmetrical polyneuropathy. Electrodiagnostic studies are recommended, since they are objective and validate tests of peripheral nerve function. Electrodiagnostic studies should not be used alone to make the diagnosis because their sensitivity and specificity are not perfect.
The case definition will be available for downloading on January 25 at www.aan.com/professionals/practice/guideline/index.cfm.
The American Academy of Neurology, an association of more than 18,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, epilepsy, Parkinson's disease, multiple sclerosis, and stroke.
For more information about the American Academy of Neurology, visit its Website at www.aan.com.
Journal
Neurology