Damien Gervasoni, Shih-Chieh Lin, Sidarta Ribeiro, Ernesto S. Soares, Janaina Pantoja, and Miguel A. L. Nicolelis
Just as behavior differs greatly between waking and sleep states, so too does electrical brain activity, from the fast oscillating pattern of wakefulness to the slower waves of sleep states and then back to the fast activity associated with rapid eye movement (REM) sleep. This week, Gervasoni et al. examine the dynamics of the wake–sleep cycle.
2. Insulin, IDE, and Beta-Amyloid
Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P. Lim, Surendra S. Ambegaokar, Oliver J. Ubeda, Sally A. Frautschy, and Greg M. Cole
Insulin-degrading enzyme (IDE), despite its name, can also degrade Beta-amyloid (Aβ) peptide that accumulates in Alzheimer's disease (AD). There are some tantalizing clues linking IDE and AD. This week Zhao et al. examine several aspects of this idea.