In a Keynote Address during the 82nd General Session of the International Association for Dental Research, Iain Chapple (University of Birmingham, UK) will report on an assay for total anti-oxidant capacity, with sufficient sensitivity to permit analysis of gingival crevicular fluid as well as plasma compartments. With collaborators, he has developed a regression model that allows for the prediction of total anti-oxidant capacity from individual anti-oxidant components in serum, thereby facilitating the interrogation of large databases such as the National Health and Nutrition Examination Survey III.
They have also demonstrated a unique anti-oxidant profile for GCF, distinct from plasma, but similar to the alveolar-lining fluids of the lungs and cervix. Data will be presented on all aspects of this work, and a new hypothesis supporting a role for reduced glutathione and total anti-oxidant deficiency in periodontal disease pathogenesis will be proposed. This opens up the potential for a new generation of novel, dual-action host-modulation therapies, or "neutraceuticals", as adjuncts in the management of inflammatory periodontitis.
This is a summary of a Keynote Address entitled "Nutrition and Oxidative Stress in Periodontal Disease", to be presented by I. Chapple (University of Birmingham, UK), at 8 a.m. on Saturday, March 13, in Room 306-B of the Hawaii Convention Center during the 82nd General Session of the International Association for Dental Research.
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