"One of the challenges of treatment planning for radiation therapy is pinpointing radiation precisely to target a tumor and decreasing the amount of healthy tissue that may be exposed to radiation," said Andrew Wu, Ph.D., director of medical physics at UPMC. "Tumors are akin to moving targets. As a patient inhales and exhales, the tumor moves, making it challenging to target the tumor and to avoid exposure of radiation to the area that surrounds the tumor."
According to Dr. Wu, Adv4D is promising because it is one of the first technologies of its kind to allow physicists to perform respiratory gating – precisely following the movement of a tumor according to a patient's breathing cycle.
"What makes GE's Advantage 4D CT respiratory gating system different than any other similar software is the ability to superimpose tumor or organ definitions over CT images in a movie loop," said Bob Beckett, global manager, CT oncology for GE Medical Systems. "This unique advantage allows doctors to confidently evaluate the effects of motion on target volumes to help ensure the tumor receives the full amount of the treatment dose."
UPMC is one of five centers across the country currently evaluating Adv4D. Results from the first 15 patients evaluated at UPMC indicate that the technology improves the ability to develop more precise treatment plans. Preliminary findings show that this technology incorporated with intensity modulated radiation therapy (IMRT) – a radiation technology that allows the delivery of extremely precise doses of radiation to destroy cancer cells while minimizing harm to surrounding normal and healthy tissues – may potentially allow lung and ovarian cancer patients to be treated with high precision and low complications.