The sequencing of the mouse genome is a major milestone in modern biology as it is the only mammalian genome, other than human, to have been sequenced. The mouse genome will help the research effort to interpret the human genome sequence because the mouse carries a very similar set of genes to humans. For many human diseases, major breakthroughs have come from the study of mouse disease models. The availability of the mouse sequence will now help identify the part played by genetics in many human diseases, leading to better understanding of disease and both improved diagnostic tests and treatments.
Zhang and colleagues are the first researchers to compare these different genome sequences. As this is just the beginning of a new era of comparative mammalian genomics, they hope that their preliminary work will provide a springboard to further our understanding. Because it is so important for progress that all data are made freely available, Zhang and colleagues are making their database of conserved sequence elements available to all over the web, and they have chosen to publish their research in a journal that provides free full-text access to all research articles immediately on publication.
The full text of this article will be freely available from the Genome Biology website on the 5th December 2002: http://genomebiology.com/
Journal
Genome Biology