"Functional genomics is the hottest topic in cancer research today," says William Dalton, PhD, MD, Moffitt's new CEO and Center Director. "It could completely change the practice of medicine within five years."
The resolution of the human genome into separate genes provided the blueprint for understanding disease processes. However, unraveling the functional significance of these genes is central to solving the problems posed by cancer and other diseases. "Each cancer is unique" explains Jack Pledger, PhD, Moffitt's Deputy Director and head of basic research, who will also serve as Scientific Director of the NFGP. "We need to pay attention to the molecular changes that give rise to cancer, rather than just looking at where the cancer started out. Molecular diagnosis may be better than a diagnosis based on just what the tumor looks like--or whether it started out in the lung, prostate, or breast."
The primary function of the NFGP will be to track the genetic changes involved in cancer, allowing the design of more effective therapeutic agents and a better understanding of the hereditary and environmental influences that contribute to cancer and other diseases. "We need a new way to classify tumors," says Pledger. "The current method of categorizing them based solely on the tissue they arise in is not adequate for relating how they respond to chemotherapy."
The NFGP will be an integrated research program focusing on gene expression analysis, genetics, proteomics, and translational research, with a bioinformatics program to support the analysis and interpretation of gene expression data and integrate data generated from the NFGP with that from other institutes. Moffitt's track record of translational research--speedy movement of laboratory findings into patient care--will allow researchers to meet the federal goal of quickly evaluating potential for commercial development of technologies and will allow government beneficiaries more rapid access to new technologies and advances in health care. The inclusion of corporate partners into the NFGP will also accelerate the translation of molecular medicine derived from the laboratory directly into early detection and clinical treatment.
Situated on the campus of the University of South Florida, the H. Lee Moffitt Cancer Center & Research Institute is a world-renowned cancer treatment and research facility. In 2001 the National Cancer Institute awarded it the status of a Comprehensive Cancer Center - in recognition of its excellence in research and contributions to clinical trials, prevention and cancer control. Additionally, Moffitt is a member of the National Comprehensive Cancer Network, a prestigious alliance of the country's leading cancer centers, and is listed in the U.S. News & World Report as one of Top 10 cancer hospitals in America. Moffitt's sole mission is to contribute to the prevention and cure of cancer.
The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office for this grant (Award Number DAMD17-02-0051). The content of this release does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.