Mesothelioma is a cancer of the pleura – the membranes that lines the inside of the chest and the outside of the lungs. It differs from other types of lung cancer in that it is caused by exposure to asbestos, rather than by smoking. The condition affects five times more men than women, and most commonly develops in men between 50 and 70 years of age.
Mesothelioma is very hard to treat. It is usually inoperable and not very responsive to radiotherapy. With the anticancer drugs previously available, people diagnosed with the disease could expect to survive for only six to eight months.
Now, results of a study by Professor Hilary Calvert, Dr Andrew Hughes and colleagues in the Cancer Research UK-funded Cancer Research Unit at Newcastle University, in collaboration in Eli Lilley, have shown that, on average, patients who were given the new drug, pemetrexed and carboplatin, survived for up to 13 – 14 months. In a handful of cases, patients have survived for three years or more.
Professor Calvert said: 'The drug combination showed remarkable activity in Mesothelioma. Indeed, our study provided the first convincing demonstration that pemetrexed to carboplatin could be useful in the treatment of the disease'.
Pemetrexed is an experimental drug being developed by pharmaceutical company Eli Lilley under the trade name Alimta. It is an anticancer drug based on being an analogue of the B-vitamin, folic acid. Drugs of this class were first developed by Professor Calvert and colleagues at the Institute of Cancer Research in London in the early 1980s with funding from Cancer Research, leading to the licensing of a drug called raltitrexed (Tomudex).
Because the interval between exposure to asbestos and developing Mesothelioma can be 30 – 40 years, the incidence of the disease is still on the rise, as a result of industrial exposure to asbestos in the 70s and 80s. Currently there are about 1,700 cases per year in the UK, with that figure expected to more or less double by 2020.
The results of the Newcastle trial led Eli Lilley to sponsor a multinational randomised trial in Mesothelioma which was reported at this year's American Society for Clinical Oncology meeting. The trial showed an improvement of survival and symptoms for the first time in Mesothelioma.
Dr Lesley Walker, Director of Cancer Information at Cancer Research UK says: 'Mesothelioma is a serious condition that is difficult to treat so this is an important development. We now need to look closely at the drugs performance in the next stages of clinical trials to see how it compares to other anti-cancer drugs.'
Notes for Editors
- Contact: Prof. Hilary Calvert via his secretaries on 0191 222 8057 or 219 4250.
- The report of the Newcastle research team 'Phase I Clinical and Pharmacokinetic Study of Pemetrexed and Carboplatin in Patients With Malignant Pleural Mesothelioma' is published in the Journal of Clinical Oncology 20(16), 2002. The researchers involved are Andy Hughes, Paula Calvert, Ashraf Azzabi, Ruth Plummer, Rob Johnson, Jim Rusthoven, Melanie Griffin, Kevin Fishwick, Alan V. Boddy, Mark Verrill, and Hilary Calvert.
- A copy of the research paper is available on request. Please contact 0191 222 7850 or e-mail press.office@ncl.ac.uk
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Journal
Journal of Clinical Oncology