Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease.
Three tumor samples collected over time from a single patient shows how cancer evolves in response to treatment: A higher percentage of cancer stem cells in the final sample make a more aggressive disease.
Researchers have identified a therapeutic target to prevent or delay heart failure from pressure overload of the heart, and a potential biomarker for the same. They say their animal studies carry clinical and translational potential. Mouse-model experiments showed that preventing the early infiltration of CCR2+ macrophages into the heart, after experimental pressure overload, significantly lessened the heart's enlargement and reduced pumping ability that leads to later heart failure.
People with tough-to-treat triple negative breast cancer, whose tumors also don't allow for double-strand DNA repair, fare better when treated with a common adjuvant breast cancer chemotherapy combination, according to results from a SWOG clinical trial.
Children with mild to moderate asthma do not benefit from a common practice of increasing their inhaled steroids at the first signs of an asthma exacerbation, according to clinical trial results published in The New England Journal of Medicine. Researchers found short-term increases in inhaled steroids did not prevent attacks in children aged 5 to 11, and may even slow a child's growth.
A meta-analysis study by University of Cincinnati researchers shows for the first time that SSRIs may be the more effective antidepressant treatment for youth anxiety disorder.
Biomedical engineers from Duke University have demonstrated a new approach to making self-assembled biomaterials that relies on protein modifications and temperature. The hybrid approach allows researchers to control self-assembly more precisely, which may prove useful for a variety of biomedical applications, from drug delivery to wound-healing.
Scientists have discovered a curious way for cells to die. In studying it, they are learning about how remnants of diseased cells are normally chewed up and removed.
Research from a UC Santa Cruz Genomics Institute-affiliated team just published in the journal Nature Biotechnology attempts to close huge gaps remain in our genomic reference map. The research uses nanopore long-read sequencing to generate the first complete and accurate linear map of a human Y chromosome centromere. This milestone in human genetics and genomics signals that scientists are finally entering a technological phase when completing the human genome will be a reality.
A new report details three cases of secondary brain tumors in people with fibrolamellar hepatocellular carcinoma. The researchers say imaging tests could improve treatment for patients whose cancer spreads to the brain from the liver.