New therapeutic approach to treating idiopathic pulmonary fibrosis. A key factor in the development of the disease is low levels of activity of the FoxO3 transcription factor. Experiments on mice have shown that treatment with UCN-01 stops progression of the disease and even reduces symptoms. The illustration shows a schematic representation of a diseased and a healed lung (top), and tissue preparations from the lung of a mouse with idiopathic pulmonary fibrosis (left) and a mouse after treatment with UCN-01 (right).
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