Antibiotic use in farming and human health leads to bacteria acquiring resistance (indicated by a + sign in the illustration). Antibiotic-resistant bacteria in the environment are picked up by honey bees during pollination. In the bee's gut, genetic material for resistance "jumps" to natural gut bacteria, which can spread resistance further. Overuse of antibiotics (USA) leads to more widespread and elaborate patterns or resistance (indicated by multiple colors of + signs). Restricted antibiotic use (Norway) leads to limited and less complex patterns of resistance.