Enzyme Cascade (image) Penn State Share Print E-Mail Caption Like ants, one enzyme follows the trail left behind by the previous one. In this case, the initial substrate is acted upon by enzyme A, leaving a substrate suitable for enzyme B and on down the line. Credit Ayusman Sen, Penn State Usage Restrictions Non commercial use only Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.