(A) Upper: Schematic of EGFR (red) and PPARGC1A (blue) gene structures as related to EGFR-PPARGC1A fusion transcript formation. Lower: Predicted amino acid sequence and EGFR-PPARGC1A fusion transcript partial sequence at the break point. (B) The locations of cSCC tumors of 102 patients. Red dots are positive for EGFR-PPARGC1A fusion and blue dots are negative.
[This image has been modified from the original (Fig. 1 & Fig. 2) of Egashira, S. et. al. (2017). Chronic sun exposure-related fusion oncogenes EGFR-PPARGC1A in cutaneous squamous cell carcinoma. Scientific Reports, 7(1). doi:10.1038/s41598-017-12836-z.]