Destabilization and Dissociation of the Ribosome (image) Tokyo Institute of Technology Share Print E-Mail Caption The ribosome becomes destabilized by the protein (nascent chain) it itself synthesized (IRD) and splits apart into the large and small subunits. As a result, the protein synthesis ends mid-cycle without reaching the end point. Credit Hidekii Taguchi Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.