These are core publications in networks. The outer arcs of blue nodes identify first generation publications (citing_sid) for each therapeutic. Nodes in the inner ring are sized by a gradient proportion to total degree count with an upper limit of 30 and are colored by a gradient proportional to the number of drug connections (2 to 5). 14 publications are common to all five networks (Table3) and are colored red. The remaining nodes in the inner ring connect to between 2 and 4 drugs each and are labeled accordingly. Abbreviations: alem (Alemtuzumab), imat (Imatinib), nela (Nelarabine), ramu (Ramucirumab), suni (Sunitinib).
The above image, Fig. 2 from the paper, was generated using Cytoscape, an Open Source tool funded by the US National Institute of Health (NIH).