Neutrons Observe Vitamin B6-Dependent Enzyme Activity Useful for Drug Development (image) DOE/Oak Ridge National Laboratory Share Print E-Mail Caption An ORNL-led team used neutrons to observe the AAT enzyme, a vitamin B6-dependent protein, and found that the chemical reaction occurred only in one active site. Nuclear scattering length density maps (colored mesh) highlight the positions of critical hydrogen atoms, including a low-barrier hydrogen bond (magenta mesh) not thought to exist in AAT, which may be crucial for catalysis. Credit Jill Hemman and Andrey Kovalevsky /Oak Ridge National Laboratory, US Dept. of Energy Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.