Firing of Neurons Changes the Cells that Insulate Them (image) PLOS Share Print E-Mail Caption High-frequency stimulation is more efficient in promoting proliferation of Oligodendrocyte precursor cells (OPCs) (top row); low-frequency stimulation is more efficient in promoting differentiation of OPCs into pre-myelinating oligodendrocytes which are expected to further develop into oligodendrocytes and build myelin sheaths around the axon (bottom row). Credit Balint Nagy Usage Restrictions CC-BY. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.