Shown here are the pathological hallmarks of Alzheimer's disease, beta-amyloid plaques (brown spots), as seen both in brain and retinal tissues from deceased patients, as described in the Aug. 17 edition of Journal of Clinical Investigation Insight (Koronyo et al. 2017). The structures of these plaques in the brain and retina are very similar (classical and vascular-associated deposits; bv = blood vessel), suggesting that the retina faithfully represent the brain disease.
Image adapted from JCI Insight. 2017; 2(16):e93621. doi:10.1172/jci.insight.93621
Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease
Yosef Koronyo ... Keith L. Black, Maya Koronyo-Hamaoui
Published Aug. 17, 2017
Citation Information: JCI Insight. 2017;2(16):e93621. doi:10.1172/jci.insight.93621