Pseudouridimycin and Rifampin (image)

Caption
Structure of bacterial RNA polymerase, showing the binding sites for the new antibiotic pseudouridimycin (PUM) and the current antibacterial drug rifampin (Rif). PUM has a lower resistance rate and a smaller resistance target than Rif -- just 2 to 4 positions where alterations that result in PUM-resistance (blue) vs. 27 positions where alterations result in Rif-resistance (red) -- due to functional constraints on alteration of the binding site for PUM in the RNA polymerase active center.
Credit
David Degen and Richard H. Ebright (Rutgers University)
Usage Restrictions
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