68Ga-ABY-025 PET/CT and 18F-FDG PET/CT images at baseline with 18F-FDG PET/CT follow-up after 2 cycles of treatment in biopsy-confirmed HER2-positive disease. (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

68Ga-ABY-025 PET/CT and 18F-FDG PET/CT images at baseline with 18F-FDG PET/CT follow-up after 2 cycles of treatment in biopsy-confirmed HER2-positive disease.

Caption

68Ga-ABY-025 PET/CT and 18F-FDG PET/CT images at baseline with 18F-FDG PET/CT follow-up after 2 cycles of treatment in biopsy-confirmed HER2-positive disease. (A) Patient with high 68Ga-ABY-025 uptake (SUVmax, 21) who previously received 3 lines of treatment. 18F-FDG PET/CT follow-up showed complete metabolic response. (B) Patient with low uptake (SUVmax, 5.4) who previously received 3 lines of treatment. 18F-FDG PET/CT follow-up showed disease progression (Δ-TLG, +68%) despite HER2-targeted treatment. (C) Patient with heterogeneous 68Ga-ABY-025 uptake who previously received 7 lines of treatment. 18F-FDG PET/CT follow-up showed heterogeneous response, with lesions higher in 68Ga-ABY-025 uptake tending to have better response. Arrows indicate biopsy sites.

Credit

Images created by Alhuseinalkhudhur et al., Uppsala University Hospital in Uppsala, Sweden.

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