Proposed model of Axin1 protection against colitis via gut microbiota alterations. (IMAGE)

Engineering

Proposed model of Axin1 protection against colitis via gut microbiota alterations.

Caption

Deletion of intestinal epithelial and PC Axin1 results in altered goblet and PC morphology, increased MUC2, and decreased lysozyme expression. In addition, loss of Axin1 results in increased A. muciniphila and reduced thickness of the mucus border. The presence of A. muciniphila in Axin1 knockout mice is the driver of protection against DSS-induced intestinal inflammation.

Credit

Shari Garrett et al.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.

License

CC BY-NC-ND

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.