Elevated CXCL4 levels inhibit the TLR9 signaling pathway (IMAGE)
Caption
In the absence of CXCL4 (top row), DNA fragments (green) are delivered to TLR9 (red) in the late endosomes of B cells, with the colocalization of DNA fragments and TLR9 shown in orange, activating a cell signaling pathway that promotes the removal of self-reactive B cells. But, when CXCL4 levels are elevated (bottom row), DNA fragments fail to reach and activate TLR9, resulting in autoimmunity.
Credit
© 2023 Çakan et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20230944
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