This study indicated that ATS could bind to several critical proteins to interfere with the protein synthesis, lipid metabolism, and redox homeostasis of Plasmodium falciparum and exert its antimalarial effects. (IMAGE)

Engineering

This study indicated that ATS could bind to several critical proteins to interfere with the protein synthesis, lipid metabolism, and redox homeostasis of Plasmodium falciparum and exert its antimalarial effects.

Caption

ATS simultaneously interferes with ① redox homeostasis, ② lipid metabolism, and ③ protein synthesis in P. falciparum to exert antimalarial effects by targeting several essential proteins. DV: digestive vacuole; HZ: hemozoin; Mito: mitochondria.

Credit

Peng Gao et al.

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License

CC BY-NC-ND

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