Mechanisms underlying hyperglycemia-impaired insulin secretion in type 2 diabetes (IMAGE)

Kumamoto University

Mechanisms underlying hyperglycemia-impaired insulin secretion in type 2 diabetes

Caption

Researchers elucidate how BHLHE40, a transcriptional repressor activated in pancreatic β-cells as a response to hypoxia, inhibits the expression of the MAFA protein, thereby leading to impaired insulin secretion.

Credit

Professor Kazuya Yamagata

Usage Restrictions

Do not reuse without permission.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.