Schematic model of the pathogenic mechanism of mutant CHCHD2-induced PD (IMAGE)

Tokyo Medical and Dental University

Schematic model of the pathogenic mechanism of mutant CHCHD2-induced PD

Caption

In healthy condition, CHCHD2WT localizes in mitochondria. In pathogenic condition, mutant CHCHD2T61I mislocalizes to the cytosol and recruits Casein kinase 1 epsilon/delta (Csnk1e/d, CK1epsilon/delta). CK1epsilon/delta phosphorylate α-Synuclein and other proteins to generate aggresomes, subsequently resulting in neurodegeneration. CK1epsilon/delta inhibitors repress generation of aggresomes and neurodegeneration.

Credit

Department of Pathological Cell Biology, TMDU

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