A new enzyme-based molecular design with key implications in radiotheranostics (IMAGE)

Chiba University

A new enzyme-based molecular design with key implications in radiotheranostics

Caption

1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-based reagents, when conjugated to antibody fragments and injected into mice, produced the metabolites [111In]In-DO3AiBu-Bn-F and [111In]In-DOTA-Bn-F, which were dissimilarly eliminated by the kidneys. Quite notably, [111In]In-DO3AiBu-Bn-FGK-Fab showed the lowest renal localization without impairing tumor accumulation, thus paving the way for the possible clinical evaluation of this radiotheranostic approach.

Credit

Suzuki et al., Chiba University

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