Host and microbial ethanol metabolism and its possible contribution to microbial-related changes during ABD. (IMAGE)

First Hospital of Jilin University

Host and microbial ethanol metabolism and its possible contribution to microbial-related changes during ABD.

Caption

Acetaldehyde and acetate produced by the host may impact directly or indirectly small gut bacterial overgrowth, microbial translocation and changes in the faecal microbiota. Microbe metabolising ethanol to acetaldehyde may contribute to acetaldehyde accumulation in the gut, but more rigorous studies are required to confirm this notion. Also, colonic bacteria producing acetate could impact gut acetate levels. ABD, alcohol-associated bowel disease; PAMP, pathogen-associated molecular pattern.

Credit

By Luca Maccioni, Yaojie Fu, Yves Horsmans, Isabelle Leclercq, Peter Stärkel, George Kunos and Bin Gao.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.