Mouse stem cells reflect cold resistance levels seen in live animals and in organ tissue (IMAGE)

RIKEN

Mouse stem cells reflect cold resistance levels seen in live animals and in organ tissue

Caption

(Left) Body temperature during torpor was examined in three types of laboratory mice. (Middle) Metabolism was examined in embryonic stem cell lines generated from the three types of mice and was compared between normal (37°C/98.6°F) and cold (31°C/87.8°F) conditions. (Right) Liver tissue was sampled from each type of adult mouse and metabolism was compared. Mice that underwent deep torpor differed from the other two types: Body temperature was much lower during torpor and at low temperatures, energy generation was dominated by OXPHOS (ATP by oxygen consumption) rather than glycolysis (ATP from glucose, no oxygen needed) in the stem cells and in the liver samples from adult mice.

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RIKEN

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