Lipid metabolism triggering brain-autonomous neural repair after ischemic stroke (IMAGE)

Tokyo Medical and Dental University

Lipid metabolism triggering brain-autonomous neural repair after ischemic stroke

Caption

The neurons around an injured brain region will play major roles in promoting functional recovery through nervous system development, synapse organization, and remyelination; however, the molecular mechanisms triggering such a broad range of neural repair after brain injury remained unknown. Our study demonstrated that the secretion of PLA2G2E from perilesional neurons with ischemic stress generated DGLA and 15-HETrE, which triggered these recovery processes through the neuronal Padi4-dependent induction of cluster formation associated with neural repair after ischemic brain injury.

Credit

Department of Neuroinflammation and Repair, TMDU

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