Lipid metabolism triggering brain-autonomous neural repair after ischemic stroke (IMAGE)
Caption
The neurons around an injured brain region will play major roles in promoting functional recovery through nervous system development, synapse organization, and remyelination; however, the molecular mechanisms triggering such a broad range of neural repair after brain injury remained unknown. Our study demonstrated that the secretion of PLA2G2E from perilesional neurons with ischemic stress generated DGLA and 15-HETrE, which triggered these recovery processes through the neuronal Padi4-dependent induction of cluster formation associated with neural repair after ischemic brain injury.
Credit
Department of Neuroinflammation and Repair, TMDU
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