Insilico utilized AlphaFold-predicted protein structures to generate a series of hinge cores (IMAGE)

InSilico Medicine

Insilico utilized AlphaFold-predicted protein structures to generate a series of hinge cores

Caption

Following molecular docking, synthesis, and biological evaluation, a hit molecule targeting SIK2 was obtained with a novel scaffold. Further exploration led to the discovery of a compound with superior potency against SIK2 compared to reported inhibitors.

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Insilico Medicine

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