City of Hope-developed AOH1996 (IMAGE)

City of Hope

City of Hope-developed AOH1996

Caption

The City of Hope-developed small molecule AOH1996 targets a cancerous variant of the protein PCNA. In its mutated form, PCNA is critical in DNA replication and repair of all expanding tumors. Here we see untreated cancer cells (left) and cancer cells treated with AOH1996 (right) undergoing programmed cell death (violet).

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City of Hope

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