Interaction between NaV1.7 sodium ion channel and CRMP2 (IMAGE)
Caption
An artistic representation of the interaction between the NaV1.7 sodium ion channel and collapsin response mediator protein 2 (CRMP2). The researchers identified a unique regulatory sequence in NaV1.7 that is required for NaV1.7 function. They found that this peptide disrupted the interaction with CRMP2 and reduced excitability in sensory neurons. The researchers then showed that this peptide relieved pain in animal models, demonstrating that this interaction can be targeted to ameliorate chronic pain.
Credit
Samantha Perez-Miller and Rajesh Khanna (New York University)
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