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National Institutes of Natural Sciences

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SF1 neurons in the ventromedial hypothalamus were found to suppress inflammation in inguinal WAT in diet-induced obese mice through sympathetic nerves innervating the tissue, while they had no effect on epididymal WAT. The SF1 neurons also increased thermogenic function in interscapular BAT in diet-induced obese mice. Thus, the suppressive role of SF1 neurons in inflammatory response in subcutaneous (inguinal) WAT may explain why subcutaneous obesity has lower incidence of metabolic diseases than abdominal obesity.

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Yasuhiko Minokoshi

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