Fig. 1 (IMAGE)

Osaka University

Fig. 1

Caption

Polydom binds to Tie1 and activates the PI3K/Akt signaling pathway. (A) The domain structure of Polydom and its mutant protein. (B) Tie1 binds to Polydom, but not to its mutant. (C) Lymphatic endothelial cells of wild-type (left) and Polydom-deficient (right) mice. The PI3K/Akt pathway is inactivated in the lymphatic cells of Polydom-deficient mice.

Credit

Kiyotoshi Sekiguchi

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