Researchers in Japan unravel the mechanisms of redox-independent NRF2 stress response (IMAGE)

Juntendo University Research Promotion Center

Researchers in Japan unravel the mechanisms of redox-independent NRF2 stress response

Caption

ULK1 interacts directly with and phosphorylates the biomolecular condensate, p62 body. Phosphorylated p62 retains KEAP1 within itself and activates NRF2. The findings shed new light on the redox-independent activation of NRF2, which has an important role in stress response.

Credit

Masaaki Komatsu from Juntendo University

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