(IMAGE)

Hong Kong University of Science and Technology

Caption

The image depicts the noncanonical processing model of Microprocessors in action. The Microprocessor complex consists of DROSHA, shown in blue, and the DGCR8 dimer, represented in green. Arrowheads indicate the double cleavage action of DROSHA on pri-miRNAs. The noncanonical processing substrate is characterized by a short stem of approximately 28 base pairs and DRES (DROSHA Recognition Sites). This noncanonical mechanism is conserved across a variety of animal species.

Credit

Prof. Tuan Anh Nguyen

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