A comparison of severity and lymphoid depletion in mice infected with Wuhan, Delta, and Omicron SARS-CoV-2 and Influenza A (IMAGE)

Elsevier

A comparison of severity and lymphoid depletion in mice infected with Wuhan, Delta, and Omicron SARS-CoV-2 and Influenza A

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The results collectively demonstrate that lymphoid depletion lesions observed in the spleen serve as a crucial factor reflecting mortality rates. Lymphoid depletion accompanied by reduced APC function was a specific feature observed in the Wuhan and Delta types of SARS-CoV-2 but not in other infections such as Omicron and influenza A and had the greatest prognostic value for disease severity in mice infected with the Wuhan and Delta variants. DCs, dendritic cells; MHC, major histocompatibility complex; APCs, antigen presenting cells.

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The American Journal of Pathology

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