Close-up of the x-ray crystal structure of the Mtb CYP125 enzyme bound to one of the leading inhibitor compounds. (IMAGE)

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Close-up of the x-ray crystal structure of the Mtb CYP125 enzyme bound to one of the leading inhibitor compounds.

Caption

The synthetic expansion of a chemical structure in two directions designed to fit into the active site of Mtb cholesterol oxidase enzymes to generate a new range of inhibitors and potential anti-TB drugs. The right-hand image shows a close-up of the x-ray crystal structure of the Mtb CYP125 enzyme bound to one of the leading inhibitor compounds.

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University of Huddersfield

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