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Methanol is a green and renewable feedstock, which can be produced either from coal and natural gas, or directly from CO2 by hydrogenation. High-efficient methanol bioconversion to platform chemical 3-hydroxypropionate (3-HP) without depending on the arable land is attractive. Metabolic engineering of Ogataea polymorpha by optimizing the expression of malonyl-CoA reductase and enhancing the supply of precursor malonyl-CoA and cofactor NADPH enables 7.1 g/L 3-HP synthesis from methanol as sole carbon source.
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Chinese Journal of Catalysis
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