Figure 1 (IMAGE)
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Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acetate uptake in primary cultured astrocytes. B. Blockade effect of Mct1 gene-silencing on 14C-acetate uptake in primary cultured astrocytes. C. Representative images displaying GFAP and MCT1 expressions in primary cultured astrocytes 48 hours after adenovirus treatment. D. The adenovirus effect on 14C-acetate uptake. E. Schematic diagram of in vivo micro-PET imaging of adenovirus model. F. Representative images displaying GFAP and MCT1 expressions in adenovirus model. G. Schematic diagram of sniffer patch to record GABA current. H. Representative traces of Ca2+ signal (top) and GABA current (bottom).
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Institute for Basic Science
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