Claspin activates ATR, a lipid kinase, as a mediator foring molecule in the cellular DNA replication stress response, and activates Chk1 via its CKBD. On the other hand, during the nutrition (serum)-induced cell proliferationinitiation of proliferation from serum starvation, PI3 kinase, another lipid kinase, is activated, and Claspin recruits PDK1 via its CKBD, playing an important role in activating on of the PI3K-mTOR pathway. (IMAGE)
Caption
Claspin activates ATR, a lipid kinase, as a mediator foring molecule in the cellular DNA replication stress response, and activates Chk1 via its CKBD. On the other hand, during the nutrition (serum)-induced cell proliferationinitiation of proliferation from serum starvation, PI3 kinase, another lipid kinase, is activated, and Claspin recruits PDK1 via its CKBD, playing an important role in activating on of the PI3K-mTOR pathway.
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