Polycomb bodies (IMAGE) Trinity College Dublin Caption “Polycomb bodies”: Illustration of the results of Glancy, Wang et al. (2023) Molecular Cell. Blue PRC2.1 and PRC2.2 protein complexes target DNA in different ways, through CG-rich sequences or ubiquitin-modified histones, respectively. They catalyze different levels of the red H3K27me3 repressive mark. They recruit different versions of the green PRC1 complexes, characterized by the presence of the CBX2/4 or CBX7 proteins. PRC1 complexes promote contacts between yellow nucleosomes to mediate gene repression. Artwork by Ellen Tuck. Credit Ellen Tuck, Trinity College Dublin Usage Restrictions Please credit Ellen Tuck, Trinity College Dublin License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.